New bioactivity of N-oxide quinoline derivatives
Stage of development
Samples of N-oxide quinoline derivatives are synthesized using different chemical groups inserted in heterocycle, including electron donors and electron acceptors.
Cytotoxic, antiproliferative, apoptosis-inducing, antitumour activities of given compounds in vitro are explored.
- Comlex of laboratory technologies for assessing of biological and pharmacological activities of reagents in vivo is developed.
Aim of the project:
Creation of group of pharmacologically active agents with high antitumour and/or antibacterial activity
Use in the sphere of medicine and pharmacology as mono-preparations or as a part of combination products.
Advantages of technology:
- High percentage of synthesized compounds in reaction mixture
- High-degree substance purification
Synthesized compounds have high biological activity (including antitumour) at the implementation in micro- and nanomolar concentrations. Thereby fall-outs, which typically emerge when using other reagents with similar activities ( neurotoxicity, nephrotoxicity, hepatoxicity, leukopenia etc.) are minimized.